Mitsugumin-53: Potential biomarker and therapeutic for myocardial ischemic injury?
نویسندگان
چکیده
منابع مشابه
Plasma-derived Extracellular Vesicles Contain Predictive Biomarkers and Potential Therapeutic Targets for Myocardial Ischemic (MI) Injury.
Myocardial infarction (MI) triggers a potent inflammatory response via the release of circulatory mediators, including extracellular vesicles (EVs) by damaged cardiac cells, necessary for myocardial healing. Timely repression of inflammatory response are critical to prevent and minimize cardiac tissue injuries, nonetheless, progression in this aspect remains challenging. The ability of EVs to t...
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Metabolic syndrome is a cluster of risk factors, such as obesity, insulin resistance, and hyperlipidemia that increases the individual's likelihood of developing cardiovascular diseases. Patients inflicted with metabolic disorders also suffer from tissue repair defect. Mitsugumin 53 (MG53) is a protein essential to cellular membrane repair. It facilitates the nucleation of intracellular vesicle...
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Mitsugumin 53 (MG53), a newly identified muscle-specific protein, is an essential component of the cell membrane repair machinery in skeletal and cardiac muscle. However, the role of MG53 after burns in other tissues remains unclear. This study aims to investigate the possible roles of MG53 in the protection of the kidney after severe burn injury, and an animal scalding model of 30% of total bo...
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Mitsugumin 53 (MG53) is a muscle-specific RBCC/TRIM family member predominantly localized on small vesicles underneath the plasma membrane. Upon cell-surface lesion MG53 recruits the vesicles to the repair site in an oxidation-dependent manner and MG53-knockout mice develop progressive myopathy associated with defective membrane repair. In this report, we focus on MG53-knockout cardiomyocytes s...
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R eperfusion injury is an issue of concern to every physician treating patients with acute myocardial infarction in the 1990s. For patients without specific contraindictions to therapy presenting for medical care early in the course of myocardial infarction, an attempt at reperfusion of ischemic, but not yet necrotic, myocardium is the current standard of clinical care. Whether a patient is tre...
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ژورنال
عنوان ژورنال: Journal of Molecular and Cellular Cardiology
سال: 2015
ISSN: 0022-2828
DOI: 10.1016/j.yjmcc.2015.01.023